Cytotoxic heteroleptic heptacoordinate salan zirconium(iv)-bis-chelates - synthesis, aqueous stability and X-ray structure analysis.
نویسندگان
چکیده
Herein we report the synthesis and structural characterization of a series of novel Zr(iv)salan complexes. The initial metalation product [(L1)2Zr] is highly water sensitive while ligand exchanged [L1Zr(dipic)] hydrolyses slowly with a bis-hydroxo Zr(iv) species identified by MS as an intermediate. [L1Zr(dipic)] is cytotoxic in the range of cisplatin against two human carcinoma cell lines.
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ورودعنوان ژورنال:
- Chemical communications
دوره 52 66 شماره
صفحات -
تاریخ انتشار 2016